Background: Elevated serum uric levels were observed in clinical conditions associated with hypoxia such as heart failure, primary pulmonary hypertension and congenital heart disease but no such observation was reported among COPD patients. Therefore, we aimed to determine whether serum uric acid levels correlate with hypoxemia and COPD severity in stable and exacerbating COPD patients.
Methods: Included are 110 diagnosed COPD patients based on spirometry, grouped into stable COPD, and in acue exacerbation. Simultaneous blood extractions for serum uric acid and ABG's were determined with the patient in a steady state and in upright position. Independent t-test was employed to determine the association between serumuric acid levels with blood gas variables, age and sex. The correlation between serum uric acid levels with COPD severity was explored using ANOVA.
Results: There was a highly significant correlation between hypoxemia serum uric acid levels in both stable ad exacerbating COPD patients (p 0.05). The relation of COPD severity and seru uric acid levels showed that the higher the serum uric acid level, the more severe the COPD is among subjects in the stable COPD group (p<0.000). However, the same does not apply among the subjects in acute exacerbation (p 0.070).
Conclusion: There is a strong correlation between hypoxemia and the severity of COPD with serum uric acid level among stable COPD patients. Thus, elevated serum uric acid levels may serve as a non-invasive indicator for the severity of COPD and hypoxemia in non-exacerbbating COPD patients.