Background: Fractional exhaled nitric oxide is being used for marker of inflammation in disease activity of different lung disease. COPD is a progressive airflow obstruction with neutrophilic inflammation. We measure FeNO level in documented COPD patient whether the FeNO level is related with the severity of COPD.
Method: We measure the FeNO level of patient diagnosed with COPD thru spirometry and correlate if the FeNO level with the severy of the COPD as dictate by the lung function.
Results: We enrolled 35 COPD patients and categorized them based on Combined Gold model of symptom. Exhaled nitric oxide level were significantly higher in COPD Gold D (38.5 + 7.7 ppb) as compare with COPD Gold A (23.4 + 1.14 ppb). However, FeNO level showed weak inverse correlation with lung function assessment by %
predicted FEV1(r= 0.21, p= 0.231).
Conclusion: We conclude that FENo may me used as marker and to monitor its disease activity.