Objective: The aim of the present study was to determine the potential analgesic and antipyretic activity of volatile oil from the leaves of Blumea balsamifera in Sprague Dawley rat of either sex.
Methods: Various tests were applied, it includes physical tests and chemical tests to determine the presence of volatile oil. OECD 423 was utilized for acute toxicity testing using volatile oil of Sambong leaves of 300mg/kg for the determination of dose safe for animal testing. Analgesic effect was assessed using Tail Immersion Assay and antipyretic activity was determined by Brewer's yeast induced pyrexia in rat.
Results: The volatileoil of B. balsamifera (150mg/kg, 325mg/kg, 500mg/kg, b.wt) significantly (P<0.05mg/kg) decreased very minimal latency time in the tail immersion method and it also reduced rectal body temperature in Brewer's yeast-induced pyrexia at the starting dose of 150mg/kg body weight of volatile oil.
Conclusion: Altogether these results showed that the volatile oil of B. balsamifera has analgesic and antipyretic activities which provide a scientific evidence for its traditional claim