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Submitted: 04 September 2019 Modified: 04 September 2019
HERDIN Record #: 103096-19090414595655

THE ANALGESIC AND ANTIPYRETIC ACTIVITY OF VOLATILE OIL PRESENT IN THE LEAVES OF Blumea balsamifera Linn. (SAMBONG).

Mettia Rosh D. Rabulan,
Graziella Jel P. Refe,
Kathleen P. Santos

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Objective: The aim of the present study was to determine the potential analgesic and antipyretic activity of volatile oil from the leaves of Blumea balsamifera in Sprague Dawley rat of either sex.


Methods: Various tests were applied, it includes physical tests and chemical tests to determine the presence of volatile oil. OECD 423 was utilized for acute toxicity testing using volatile oil of Sambong leaves of 300mg/kg for the determination of dose safe for animal testing. Analgesic effect was assessed using Tail Immersion Assay and antipyretic activity was determined by Brewer's yeast induced pyrexia in rat.


Results: The volatileoil of B. balsamifera (150mg/kg, 325mg/kg, 500mg/kg, b.wt) significantly (P<0.05mg/kg) decreased very minimal latency time in the tail immersion method and it also reduced rectal body temperature in Brewer's yeast-induced pyrexia at the starting dose of 150mg/kg body weight of volatile oil. 


Conclusion: Altogether these results showed that the volatile oil of B. balsamifera has analgesic and antipyretic activities which provide a scientific evidence for its traditional claim

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Department of Pharmacy
Publication Date
April 2019
LocationLocation CodeAvailable FormatAvailability
UPH-Dr. Jose G. Tamayo Medical University/Medical Center PH274 Abstract Print Format
1. Bloom, F. . "2019. Analgesics. Retrieved February 8, 2019 from" , . Retrieved from: http://https://www.britannica.com/contributor/Floyd-E-Bloom/307
2. Chinedu, E. , Arome, D. , Ameh, F.S. . "2013. A New Method for Determining Acute Toxicity in Animal Models." Toxicology Int. 20(3): 224-226, December 2013
3. Dharmananda, S. PhD. . "RELATIONSHIP OF BORNEOL, ARTEMISIA, AND MOXA" Institute for Traditional Medicine, Portland, Oregon.